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KMID : 0390119960360010237
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Journal of Pusan Medical College
1996 Volume.36 No. 1 p.237 ~ p.242
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Measurement of Serum Soluble Interleukin 2 Receptor Levels in Patients with Myelodysplastic Syndromes
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Abstract
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A soluble form of interleukin-2 receptors(sIL-2R) is released from activated T cells. Serum sIL-2R levels are elevated in some hematological malignancies and a marked elevation could be used to assess disease activity and prognosis in this group
malignancy. The myelodysplastic syndromes(MDS) comprise a clenal disorder of an early heamopoietic progenitor cell leading to abnormal maturation of blood cells and to progressive cytopenia. To define clinical usefulness and significance as a
prognostic
marker, the serum levels of sIL-2R assessed in 28 patients with myelodysplastic syndromes and 39 cases of healthy subjects by sandwich enzyme immunoassay.
1. In MDS patients, serum sIL-2R levels (1062±507 U/mL ) were higher as compared with normal controls (643±164 U/mL ).
2. A more pronounced increase of serum sIL-2R levels was found in patients with RAEB, RAEBt, and CMML(1342±518 U/mL ) as compared with RA and RARS (838±146 U/mL).
3. Serum sIL-2R levels correlated neither with WBC, Hb or Platelets. In patients with leukemic conversion, SIL-2R levels were not significantly different from patients with non-conversion. No significant differences of sIL-2R levels were
detected
between those surviving 1 year after diagnosis and those who died within 1 year.
This study indicates that serum sIL-2R levels are higher in some patients with myelodysplastic syndromes and increased levels of serum sIL-2R may be useful for predicting immune status and prognosis of these patients.
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KEYWORD
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